These mutant mice exhibit some molecular abnormalities and behavioral abnormalities, such as abnormal food intake, food preference and neurological behaviors characterized by deficit in learning ability. ĬD36 knockout (CD36 −/−) mice carry a targeted mutation in exon 3, which encodes the first 40 amino acids and the translation initiation site, is replaced by a NEO cassette (in opposite orientation). In particular, CD36 has been proposed to play role in the pathogenesis of neuropsychiatric diseases, e.g., Alzheimer’s disease, ,. The abnormal expression of CD36 might contribute to various diseases, such as glucose intolerance, atherosclerosis, arterial hypertension, diabetes, and cardiomyopathy.
It is mainly involved in fatty acid, glucose and lipid metabolism. These findings suggest that CD36 −/− mice present an anxious phenotype and might be involved in neuropsychiatric disorders.ĬD36 is a member of the class B scavenger receptor family of cell surface proteins composed of a single polypeptide chain whose size ranges, depending on the cell type, from 78 to 88 kDa. Meanwhile, the numbers that CD36 −/− mice entered in the open arms of elevated plus-maze were reduced. The CD36 −/− mice spent more time and traveled longer distance in periphery zone in the open-field test. The results showed that CD36 −/− mice traversed more squares, emitted more defecation, exhibited higher tail elevation and had more aggressive behaviors than C57BL/6J mice.
REFLEX ARENA BLACK SCREEN SERIES
We characterized the behavior of CD36 −/− mice and C57BL/6J mice by subjecting them to a series of tests, which include SHIRPA primary behavioral screen test, 1% sucrose preference test, elevated plus-maze test, open-field test and forced swimming test. The aim of this study was to achieve a behavioral phenotype of CD36 knockout (CD36 −/−) mice. Regarding this, we suggest CD36 might also contribute to neuropsychiatric disease. Besides, CD36 functions as a microglial surface receptor for amyloid beta peptide. CD36 is a member of the class B scavenger receptor family of cell surface proteins, which plays a major role in fatty acid, glucose and lipid metabolism.
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